Amino Acid-Protecting Groups
نویسندگان
چکیده
منابع مشابه
Amino acid-protecting groups.
Albert Isidro-Llobet, Mercedes Álvarez, Fernando Albericio Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028Barcelona, Spain. CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028-Barcelona, Spain. Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028Bar...
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Factors affecting aspartimide formation, such as protecting groups, acidity, basicity, and temperature, were studied using the model tetrapeptide, Glu-AspGly-Thr. The aspartyl carboxyl side chain in this tetrapeptide was either free or protected as a benzyl or cyclohexyl ester. Our results showed that the cyclohexyl ester led to far less aspartimide formation during acidic or tertiary amine tre...
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Cys-disulfide bonds contribute to the stabilization of peptide and protein structures. The synthesis of these molecules requires a proper protection of Cys residues, which is crucial to prevent side-reactions and also to achieve the correct Cys connectivity. Here we undertook a mechanistic study of a set of well-known acid-labile Cys protecting groups, as well other new promising groups, in ord...
متن کاملTunable acid-sensitive ester protecting groups in oligosaccharide synthesis.
A series of acid-cleavable ester-type protecting groups, with acid-sensitivity profiles parallel to those of 2-naphthylmethyl (NAP) or p-methoxybenzyl (PMB) ether, were designed and TFA in toluene was identified as a technically simple and effective deblocking cocktail for their global removal in the context of oligosaccharide synthesis.
متن کاملNovel Amino Protecting Group Chemistry
Functional group incompatibility in the synthesis of complex organic molecules has been a problem since the infancy of organic chemistry. Emil Fischer made a valuable contribution to organic chemistry when he came up with the notion that an otherwise reactive functional group could be temporarily rendered inert by attaching a suitable protecting group that could then later be removed [1]. Today...
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ژورنال
عنوان ژورنال: Chemical Reviews
سال: 2009
ISSN: 0009-2665,1520-6890
DOI: 10.1021/cr800323s